This online resource contains over 1200 seminar style talks containing the latest research, developments as well as the fundamentals from many of the world's leading experts in their respective fields, including Nobel Laureates.
1. The Blood-Brain Barrier (2009)
Understanding the regulatory gatekeeper between brain and body
Prof. Abba Kastin - Pennington Biomedical Research Center, USA
Prof. Weihong Pan - Pennington Biomedical Research Center, USA
Structure of the blood-brain barrier - Models - Nutrient transport - Peptides and proteins - Overcoming the blood-brain barrier obstacle - Diseases involving the blood-brain barrier.
2. Neurodegenerative Diseases (2010)
Fundamentals, Research Methods, Latest Advances
Prof. John Hodges - MRC Cognition and Brain Sciences Unit, University of Cambridge, UK
Major neurodegenerative diseases - Alzheimer's disease - Frontotemporal dementia - Parkinson's disease - Huntington's disease - Motor Neurone Disease - Clinical features - Epidemiological facts - Natural history - Prognosis - Structural and functional neuroimaging - Pathology - Molecular and genetic aspects - Mouse models - Immuno and cell-based therapies.
3. Epilepsy and Seizures (2011)
Prof. Steven Schachter - Harvard University Medical School, USA
Introduction to epilepsy - The epidemiology of epilepsy - Classification of seizures and diagnosis in adults - Epilepsy in children - Neuroimaging - Electroencephalography - Pharmacological treatment - Nonepileptic seizures - Status epilepticus - Surgical evaluation and treatments - Brain stimulation - Alternative therapies - Neuropsychological aspects - Psychiatric aspects - Stigma - Genetics of epilepsy - Epileptogenesis - Animal models - Global treatment gap
4. Cognitive Neuroscience (2010)
Prof. James McClelland - Stanford University, USA
Prof. Matthew Lambon-Ralph - University of Manchester, UK
How the brain carries out cognitive tasks - How the brain represents information - How the brain learns - Visual perception and spatial awareness - Attention - Cognitive control and executive functions - Motor control and sensory-motor integration - Language comprehension and production - Reading - Brain representation of semantic knowledge - The brain basis of memory - Development - Developmental disorders - Decision making - Cognition and emotion - Social cognitive neuroscience - The neural basis of consciousness - Behavioral analysis of cognitive abilities - Non-invasive imaging methods: fMRI, EEG, MEG - Use of non-human animals to investigate the neural basis of cognition - Computational modeling approaches
5. Neurotrauma (2011)
Prof. Norman Saunders - University of Melbourne, Australia
Traumatic brain injury (TBI): basic mechanisms and therapeutic directions - Basic mechanisms of spinal cord injury (SCI) - Immune response to SCI - Experimental TBI and SCI - Behavioral methods for assessing outcomes from TBI and SCI and effects of therapy - Spinal cord central pattern generators in SCI - Astrogliosis and scar formation after neurotrauma - Disruption of autonomic functions in SCI - Experimental approaches to developing and evaluating novel treatments for TBI and SCI - Translation from bench to bedside in neurotrauma - Clinical care of traumatic brain injury - Clinical care of SCI - Clinical care of autonomic dysfunction following SCI - Sports related traumatic brain injury - Promoting neuroplasticity for functional recovery after SCI injury - Rehabilitation following SCI - Rehabilitation following TBI - Therapies for spinal cord injury: perspectives from industry - SCI pain management - Patients perspectives: acute SCI - Patients perspectives: chronic SCI - Patients perspectives: TBI
6. Cerebrovascular Disease (2008)
Diagnosis, Treatment and Prevention - a prioritized approach
Prof. Vladimir Hachinski - University of Western Ontario, Canada
Perspective and pathogenesis - The brain and its blood supply - Mechanisms of brain ischemia and haemorrhage - The diagnosis and investigation of stroke - The treatment of stroke - Rehabilitation - Prevention - Stroke in the young - Stroke in women - Controversies and answers
7. Viruses and Viral Diseases (2010)
Emerging threats to humans and animals
Prof. Peter Palese - Department of Microbiology, Mount Sinai School of Medicine, USA
Structure and characteristics of viruses - Antiviral strategies - Vaccines and their successful uses - Important medical pathogens: HIV, influenza and hepatitis viruses - Biothreat agents - Viruses affecting the respiratory system - Viruses affecting the gastrointestinal system - Viruses targeting the brain.
8. Microarrays (2009)
Their design and use
Prof. Craig Tomlinson - Departments of Medicine and Pharmacology & Toxicology, Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, USA
An introduction to microarrays - How to design a successful microarray experiment - The use of statistics in microarray studies - The bioinformatics of microarrays - Microarray analysis of transcription to elucidate regulatory transcription factors - ChIp-on-chip: microarrays to study estrogen receptor binding sites - Microarrays of polysomes to understand cancer - Interactome networks - Single nucleotide polymorphism microarrays in the analysis of cancer - MicroRNA expression patterns in cancer - Microarrays in the study of the basic mechanisms of evolution - Genome analysis shows environmental stimuli sculpt the brain in cichlid fish - Microarrays to study the epigenetics of plants - Arsenic levels found in the United States alters gene expression in mouse lung - A systems biology approach to cancer
9. Physiology and Pathophysiology of Neuroglia (2011)
Prof. Alexei Verkhratsky - University of Manchester, UK
Where the thoughts dwell: history of neuroscience, neurones and neuroglia - General physiology of astroglia - Gliotransmission - Neuronal-glial bi-directional networking: examples of purinergic and glutamatergic signalling - General physiology of oligodendroglia and Schwann cells - General physiology of microglia - Glia and neuropathology: astrocytes - Glia and neuropathology: oligodendrocytes and microglia - The neuronal-glial networks as a substrate of brain function: shall we reconsider the neuronal doctrine?
10. Alzheimer's Disease (2010)
Prof. John Hardy - Institute of Neurology, University College London, UK
The clinical syndrome - Lewy body dementia - The pathology - The genetics of early onset disease Late onset Alzheimer's disease - App as a therapeutic target - Immunization as a therapeutic target - Tau as a therapeutic target - Vascular risk factors - What have clinical trials taught us so far? - Imaging in clinical trials - Amyloid imaging - A contrary view - Abeta toxicity - Where do we need to go?
11. Obesity (2010)
Epidemiology, Etiology, Consequences and Treatment
Prof. Claude Bouchard - George A. Bray Jr. Chair in Nutrition and Executive Director, Pennington Biomedical Research Center, Louisiana State University System, USA
Assessment of obesity and classification of patients - Obesity prevalence - Metabolic, adipose tissue and skeletal muscle predictors - Brain and peripheral regulators of energy balance - Genetic predisposition - Dietary determinants - Physical activity and low energy expenditure - Socio-cultural, built environment and economic determinants - Fetal life, birth weight, epigenetic events and obesity - Obesity and mortality rates - Obesity, dyslipoproteinemia and inflammation - Obesity, hypertension and cardiovascular disease - Obesity, diabetes and the cluster of the metabolic syndrome - Obesity, mental health and eating disorders - Obesity and quality of life indicators - Economic costs of obesity - Behaviour modifications - Pharmacotherapies - Bariatric surgery - Obesity prevention and the obesogenic environment.
12. Autism and Autism Spectrum Disorders (2010)
History, Diagnosis, Neurobiology, Treatment and Outcome
Prof. Fred Volkmar - Yale University School of Medicine, USA
An introduction to autism and related conditions - Autism and Asperger's syndrome - Rett's, CDD and regressive autism - Atypical autism/PDD-NOS - Epidemiology, gender and cultural issues - Autism in infants and young children - The school age child with autism/ASD - Adolescents and adults with autism - Diagnostic and screening instruments - Psychological assessment - Speech-communication assessment - Sensory-motor assessments - Model intervention programs - Behavioral interventions - Communication and social skills interventions - Psychopharmacology - Genetics - Brain mechanisms - Neurochemistry - Neuropsychological models - Translating research into homes and schools - Legal issues - Supporting families and siblings - Alternative treatments - Providing medical care
13. Innate Immunity (2009)
Host recognition and response in health and disease
Prof. Siamon Gordon - National Institutes of Health, USA
Drosophila - Humoral innate immunity - Innate immunity of the lung and adaptation to air breathing at birth - PMN and respiratory burst - Eosinophils - Leukocyte recruitment in vivo - Chemokines - Innate-like lymphocytes - Monocyte/macrophages in innate immunity - Dendritic cells: linking innate to different forms of adaptive immunity - Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity - Colony stimulating factor-1 regulation of macrophages in development and disease - Innate immunity and malaria - Fc receptors: linking innate and acquired immunity - Phagocytosis - Clearance of apoptotic cells and the control of inflammation - Signaling by innate immunity receptors - Type I interferons - Antigen processing and presentation - Arginase and nitric oxide - Cytokines regulating the innate response - Innate immune sensing and response - Human genetics hyper inflammatory syndrome - Tuberculosis - Cytosolic recognition - Nuclear receptors at the crossroads of inflammation and atherosclerosis - Novel lipid mediators in resolution of inflammation - Iron metabolism and innate immunity - From bench to bedside: evolution of anti-TNFα therapy in rheumatoid arthritis - Manipulation of innate immune response: lessons from shigella - NOD-like receptors in innate immunity and inflammatory disease - Innate immunity in children - HIV and immunopathogenesis - Innate recognition of viruses - Phagocytosis in Drosophila melanogaster - The fate of monocytes in atherosclerosis - Cationic peptides in innate immunity - The taste of a fungus: recognition of Candida by the innate immune system - Innate immunity in the brain in health and disease - Paneth Cells and innate immunity - Innate immunity in C. elegans - Macrophages and systems biology